David G Hangauer: search on Z-Library

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1

Non-additivity of Functional Group Contributions in Protein–Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

Bernhard Baum, Laveena Muley, Michael Smolinski, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.74 MB

english, 2010

2

Prevention of noise-induced hearing loss with Src-PTK inhibitors

Kelly Carney Harris, Bohua Hu, David Hangauer, Donald Henderson

Journal:

Hearing Research

Year:

2005

Language:

english

File:

PDF, 365 KB

english, 2005

3

The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase.Part 1: Hydroxynaphthalene derivatives

Thomas H Marsilje, Karen L Milkiewicz, David G Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 131 KB

english, 2000

4

Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors

Eric C. Bielefeld, David Hangauer, Donald Henderson

Journal:

Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 741 KB

english, 2011

5

Drug Resistance to EGFR Inhibitors in Lung Cancer

Tetsu, Osamu, Hangauer, Matthew J., Phuchareon, Janyaporn, Eisele, David W., McCormick, Frank

Journal:

Year:

2016

Language:

english

File:

PDF, 899 KB

english, 2016

6

ChemInform Abstract: The Design, Synthesis, and Activity of Non-ATP Competitive Inhibitors of pp60c-src Tyrosine Kinase. Part 2. Hydroxyindole Derivatives.

Karen L. Milkiewicz, Thomas H. Marsilje, Richard P. Woodworth Jr., Neil Bifulco Jr., Matthew J. Hangauer, David G. Hangauer

Journal:

Year:

2000

File:

PDF, 33 KB

2000

7

The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase. Part 2: Hydroxyindole derivatives

Karen L Milkiewicz, Thomas H Marsilje, Richard P Woodworth Jr., Neil Bifulco Jr., Matthew J Hangauer, David G Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 131 KB

english, 2000

8

An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model

Tu, Chengjian, Li, Jun, Bu, Yahao, Hangauer, David, Qu, Jun

Journal:

Journal of Proteomics

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

9

Dissecting the Hydrophobic Effect on the Molecular Level: The Role of Water, Enthalpy, and Entropy in Ligand Binding to Thermolysin

Biela, Adam, Nasief, Nader N., Betz, Michael, Heine, Andreas, Hangauer, David, Klebe, Gerhard

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

10

Additivity or cooperativity: Which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?

Nasief, Nader N., Hangauer, David

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.77 MB

english, 2015

11

Ligand Binding Cooperativity: Bioisosteric Replacement of C=O With SO2 Among Thrombin Inhibitors

Said, Ahmed M., Hangauer, David G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 923 KB

english, 2016

12

Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties

Tobias Brandt, Nicole Holzmann, Laveena Muley, Maan Khayat, Christof Wegscheid-Gerlach, Bernhard Baum, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 2.44 MB

english, 2011

13

Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors

Said, Ahmed M., Hangauer, David G.

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.85 MB

english, 2015

14

Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src

Nair, Shrikumar A., Kim, Moon H., Warren, Stephen D., Choi, Sun, Songyang, Zhou, Cantley, Lewis C., Hangauer, David G.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.15 MB

english, 1995

15

KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer

Muralidharan Anbalagan, Latonya Carrier, Seth Glodowski, David Hangauer, Bin Shan, Brian G. Rowan

Journal:

Breast Cancer Research and Treatment

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

16

Synthesis of a Vicinal Tricarbonyl Amide Derivative of l -Phenylalanine

Lai, Jack H., Pham, Ha, Hangauer, David G.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 135 KB

english, 1996

17

Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells

Saperstein, Richard, Vicario, Pasquale P., Strout, H. Vincent, Brady, Edward, Slater, Eve E., Greenlee, William J., Ondeyka, Debra L., Patchett, Arthur A., Hangauer, David G.

Journal:

Year:

1989

Language:

english

File:

PDF, 948 KB

english, 1989

18

Synthesis of Orthogonally Protected L-Homocysteine and L-2-Amino-4-phosphonobutanoic Acid from L-Homoserine

Nair, Shrikumar A., Lee, Bongyong, Hangauer, David G.

Journal:

Year:

1995

File:

PDF, 499 KB

1995

19

AKT inactivation causes persistent drug tolerance to EGFR inhibitors

Tetsu, Osamu, Phuchareon, Janyaporn, Eisele, David W., Hangauer, Matthew J., McCormick, Frank

Journal:

Pharmacological Research

Year:

2015

Language:

english

File:

PDF, 793 KB

english, 2015

20

Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation

Nasief, Nader N., Said, Ahmed M., Hangauer, David

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.69 MB

english, 2016

21

Live-Cell Imaging of Cellular Proteins by a Strain-Promoted Azide–Alkyne Cycloaddition

Dr. Kimberly E. Beatty, Dr. John D. Fisk, Dr. Brian P. Smart, Ying Ying Lu, Dr. Janek Szychowski, Dr. Matthew J. Hangauer, Dr. Jeremy M. Baskin, Prof. Carolyn R. Bertozzi, Prof. David A. Tirrell

Journal:

Year:

2010

Language:

english

File:

PDF, 356 KB

english, 2010

22

Total synthesis of pseudoguaianes—I: Preparation of bicyclo[5.3.0]decane synthons for damsinic acid and helenanolides

Peter T. Lansbury, Algirdas K. Serelis, John E. Hengeveld, David G. Hangauer Jr.

Journal:

Year:

1980

Language:

english

File:

PDF, 835 KB

english, 1980

23

The design, synthesis and activity of pentapeptide pp60c-src inhibitors containing L-phosphotyrosine mimics

JACK H. LAI, THOMAS H. MARSILJE, SUN CHOI, SHRIKUMAR A. NAIR, DAVID G. HANGAUER

Journal:

Chemical Biology & Drug Design

Year:

1998

Language:

english

File:

PDF, 1.14 MB

english, 1998

24

Privileged scaffolds for blocking protein–protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX–PBX/DNA

Tao Ji, Madison Lee, Steven C. Pruitt, David G. Hangauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 301 KB

english, 2004

25

Modeling the Mechanism of Peptide Cleavage by Thermolysin

DAVID G. HANGAUER, PETER GUND, JOSEPH D. ANDOSE, BRUCE L. BUSH, EUGENE M. FLUDER, EUGENE F. McINTYRE, GRAHAM M. SMITH

Journal:

Annals of the New York Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 787 KB

english, 1985

26

Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO – Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes

Nasief, Nader N., Tan, Hongwei, Kong, Jing, Hangauer, David

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.00 MB

english, 2012

27

A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

David G. Hangauer Jr.

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 176 KB

english, 1981

28

Think Twice: Understanding the High Potency of Bis(phenyl)methane Inhibitors of Thrombin

Bernhard Baum, Laveena Muley, Andreas Heine, Michael Smolinski, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 2.09 MB

english, 2009

29

Zerlegung des hydrophoben Effekts auf molekularer Ebene: Die Rolle von Wasser, Enthalpie und Entropie bei der Ligandenbindung an Thermolysin

Biela, Adam, Nasief, Nader N., Betz, Michael, Heine, Andreas, Hangauer, David, Klebe, Gerhard

Journal:

Angewandte Chemie

Year:

2013

Language:

german

File:

PDF, 1.16 MB

german, 2013

30

Ion Current-based Proteomic Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation

Tu, Chengjian, Bu, Yahao, Vujcic, Marija, Shen, Shichen, Li, Jun, Qu, Miao, Hangauer, David G., Clements, James L., Qu, Jun

Journal:

Journal of Proteome Research

Year:

2016

Language:

english

File:

PDF, 2.43 MB

english, 2016

31

Tetrapeptide tyrosine kinase inhibitors : Enantioselective synthesis of p-hydroxymethyl-l-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-l-phenylalanine

MOON H. KIM, JACK H. LAI, DAVID G. HANGAUER

Journal:

Chemical Biology & Drug Design

Year:

1994

Language:

english

File:

PDF, 853 KB

english, 1994

32

Correction to Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC

Barb, Adam W., Leavy, Tanya M., Robins, Lori I., Guan, Ziqiang, Six, David A., Zhou, Pei, Hangauer, Matthew J., Bertozzi, Carolyn R., Raetz, Christian

Journal:

Year:

2009

Language:

english

File:

PDF, 558 KB

english, 2009

33

Enhancement of Hydrophobic Interactions and Hydrogen Bond Strength by Cooperativity: Synthesis, Modeling, and Molecular Dynamics Simulations of a Congeneric Series of Thrombin Inhibitors

Muley, Laveena, Baum, Bernhard, Smolinski, Michael, Freindorf, Marek, Heine, Andreas, Klebe, Gerhard, Hangauer, David G.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.60 MB

english, 2010

34

Influence of Neighboring Groups on the Thermodynamics of Hydrophobic Binding: An Added Complex Facet to the Hydrophobic Effect

Nasief, Nader N., Hangauer, David

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.47 MB

english, 2014

35

Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 518 KB

english, 2007

36

A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies

Aung Naing, Roger Cohen, Grace K. Dy, David S. Hong, Lyn Dyster, David G. Hangauer, Rudolf Kwan, Gerald Fetterly, Razelle Kurzrock, Alex A. Adjei…show all 10hide

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 144 KB

english, 2013

37

Total synthesis of pseudoguaianolides: (.+-.)-aromaticin and (.+-.)-aromatin

Lansbury, Peter T., Hangauer, David G., Vacca, Joseph P.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 298 KB

english, 1980

38

Thermodynamisches Inhibitionsprofil eines Cyclopentyl- und eines Cyclohexylderivats gegenüber Thrombin: gleich, jedoch aus unterschiedlichem Grund

Christof Gerlach, Michael Smolinski, Holger Steuber, Christoph A. Sotriffer, Andreas Heine, David G. Hangauer, Gerhard Klebe

Journal:

Angewandte Chemie

Year:

2007

Language:

german

File:

PDF, 518 KB

german, 2007

39

More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Nonbasic Residues in the S1 Pocket of Thrombin

Bernhard Baum, Menshawy Mohamed, Mohamed Zayed, Christof Gerlach, Andreas Heine, David Hangauer, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 796 KB

english, 2009

40

Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

Asal Fallah-Tafti, Alireza Foroumadi, Rakesh Tiwari, Amir Nasrolahi Shirazi, David G. Hangauer, Yahao Bu, Tahmineh Akbarzadeh, Keykavous Parang, Abbas Shafiee

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 453 KB

english, 2011

41

Total synthesis of erbstatin

David G Hangauer

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 261 KB

english, 1986

42

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

Hangauer, David G., Monzingo, Arthur F., Matthews, Brian W.

Journal:

Year:

1984

Language:

english

File:

PDF, 2.54 MB

english, 1984

43

Expression of Src and FAK in Hepatocellular Carcinoma and the Effect of Src Inhibitors on Hepatocellular Carcinoma In

Grace M. Lau, Gillian M. Lau, Guo-Liang Yu, Irwin H. Gelman, Alan Gutowski, David Hangauer, Jane W. S. Fang

Journal:

Digestive Diseases and Sciences

Year:

2009

Language:

english

File:

PDF, 507 KB

english, 2009

44

Dual Src Kinase/Pretubulin Inhibitor, KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen Through ERα Re-expression

Anbalagan, Muralidharan, Sheng, Mei, Fleischer, Brian, Zhang, Yifang, Gao, Yuanjun, Hoang, Van T, Matossian, Margarite D., Burks, Hope E, Burow, Matthew E, Collins-Burow, Bridgette M, Hangauer, David,

Journal:

Molecular Cancer Research

Year:

2017

Language:

english

File:

PDF, 8.70 MB

english, 2017

45

C-10 epimerization of hydroazulen-7-onesby vinylogus activation

Peter T. Lansbury, David G. Hangauer

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 202 KB

english, 1979

46

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

Smolinski, Michael P., Bu, Yahao, Clements, James, Gelman, Irwin H, Hegab, Taher, Cutler, David L, Fang, Jane W. S., Fetterly, Gerald, Kwan, Rudolf, Barnett, Allen, Lau, Johnson Y. N., Hangauer, David

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

47

KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma

Ciesielski, Michael J., Bu, Yahao, Munich, Stephan A., Teegarden, Paola, Smolinski, Michael P., Clements, James L., Lau, Johnson Y. N., Hangauer, David G., Fenstermaker, Robert A.

Journal:

Journal of Neuro-Oncology

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

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